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Bardoxolone methyl ;NSC 713200; RTA 402; CDDO Methyl esterOleana-1,9(11)-dien-28-oicacid, 2-cyano-3,12-dioxo-, methyl ester;CAS: 218600-53-4

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Synonyms: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oicacid methyl ester; Bardoxolone methyl; CDDO Methylester; CDDO-Me; Methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate; NSC713200; RTA 402 Classification: Pharmaceuticals and Biochemicals
EINECS: Molecular Formula: C32H43 N O4
Melting Point: Boiling Point: 600.8°Cat760mmHg
Stability: Water Solubility:
Refractive index: 1.558 Flash Point: 256.5°C
Purity: >98% Appearance:
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Detailed Description

Bardoxolone methyl(NSC 713200; RTA 402; CDDO Methyl ester) is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2, an important biological target that controls the production of many of the body's antioxidant and detoxification enzymes. Because oxidative stress and inflammation occur throughout the course of chronic kidney disease (CKD) and are known to contribute to loss of kidney function, agents that activate the Nrf2 pathway in patients with CKD may provide a novel method for preserving or improving kidney function. Bardoxolone methyl(NSC 713200; RTA 402; CDDO Methyl ester) is currently being investigated as a potential oral once-a-day treatment for CKD.

 


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