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AZD 7762;AZD7762;AZD-7762CAS: 860352-01-8

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Quick Details
Synonyms: 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide Classification: Pharmaceuticals and Biochemicals
EINECS: Molecular Formula: C17H19FN4O2S
Melting Point: Boiling Point: 547.6 °C at 760 mmHg
Stability: Water Solubility:
Refractive index: Flash Point: 285 °C
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Detailed Description

AZD-7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. AZD-7762 significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD-7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.


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