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NVP-AUY922;AUY922; VER-52296; AUY 922; VER 52296; AUY-922; VER-52296;3-Isoxazolecarboxamide,5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-CAS: 747412-49-3

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    10 Gram
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Quick Details
Synonyms: NVP-AUY922;VER 52296;5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide; Classification: Pharmaceuticals and Biochemicals
EINECS: Molecular Formula: C26H31N3O5
Melting Point: Boiling Point: 640.1°C at 760 mmHg
Stability: Water Solubility:
Refractive index: 1.597 Flash Point: 340.9°C
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Detailed Description

NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor. NVP-AUY922 potently inhibits HSP90 (Kd = 1.7 nmol/L) and proliferation of human tumor cells with GI50 values of approximately 2 to 40 nmol/L, inducing G1-G2 arrest and apoptosis.

 


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