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ABT 737;ABT 737;ABT737CAS: 852808-04-9

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Synonyms: Benzamide,4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-;4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-Benzamide; Classification: Pharmaceuticals and Biochemicals
EINECS: Molecular Formula: C42H45ClN6O5S2
Melting Point: 152-154 °C Boiling Point:
Stability: Water Solubility:
Refractive index: 1.698 Flash Point:
Purity: >98% Appearance:
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Detailed Description

ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance, inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells.

 


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